ersiliaos/eos1soi repository overview

⁠Antimicrobial activity against non-growing bacteria

Identifies compounds able to kill uropathogenic Escherichia coli that has stopped dividing, a state in which most antibiotics lose their effect and which underlies recurrent infection. Kaldalu and colleagues screened 6,454 approved drugs and clinical candidates in dilution-regrowth assays, which register killing and delayed regrowth rather than growth inhibition. Ersilia trained a LazyQSAR classifier on the 37 compounds active in diluted cation-adjusted Mueller-Hinton broth at pH 7.4; fluoroquinolones dominate them, so the active chemistry is narrow and anchored to repurposing space.

This model was incorporated on 2025-12-17.Last packaged on 2026-10-26.

⁠Information

⁠Identifiers

• Ersilia Identifier: eos1soi
• Slug: non-growing-antimicrobial

⁠Domain

• Task: Annotation
• Subtask: Activity prediction
• Biomedical Area: Antimicrobial resistance
• Target Organism: Escherichia coli
• Tags: Antimicrobial activity

⁠Input

• Input: Compound
• Input Dimension: 1

⁠Output

• Output Dimension: 1
• Output Consistency: Fixed
• Interpretation: Rank score of the predicted ability to kill non-growing uropathogenic Escherichia coli or delay its regrowth. Calibrated against the Ersilia reference library of 50K compounds so that 0.65 is better than 99% of them. Higher is better.

Below are the Output Columns of the model:

⁠Source and Deployment

• Source: Local
• Source Type: Internal
• DockerHub: https://hub.docker.com/r/ersiliaos/eos1soi⁠
• Docker Architecture: AMD64, ARM64
• S3 Storage: https://ersilia-models-zipped.s3.eu-central-1.amazonaws.com/eos1soi.zip⁠

⁠Resource Consumption

• Model Size (Mb): 9
• Environment Size (Mb): 7512
• Image Size (Mb): 7537.65

Computational Performance (seconds):

• 10 inputs: 36.33
• 100 inputs: 26.77
• 10000 inputs: 550.56

⁠References

• Source Code: https://github.com/ersilia-os/lazy-qsar⁠
• Publication: https://doi.org/10.1038/s44259-025-00097-0⁠
• Publication Type: Peer reviewed
• Publication Year: 2025
• Ersilia Contributor: GemmaTuron⁠

⁠License

This package is licensed under a GPL-3.0⁠ license. The model contained within this package is licensed under a GPL-3.0-or-later⁠ license.

Notice: Ersilia grants access to models as is, directly from the original authors, please refer to the original code repository and/or publication if you use the model in your research.

⁠Use

To use this model locally, you need to have the Ersilia CLI⁠ installed. The model can be fetched using the following command:

# fetch model from the Ersilia Model Hub
ersilia fetch eos1soi

Then, you can serve, run and close the model as follows:

# serve the model
ersilia serve eos1soi
# generate an example file
ersilia example -n 3 -f my_input.csv
# run the model
ersilia run -i my_input.csv -o my_output.csv
# close the model
ersilia close

⁠About Ersilia

The Ersilia Open Source Initiative⁠ is a tech non-profit organization fueling sustainable research in the Global South. Please cite⁠ the Ersilia Model Hub if you've found this model to be useful. Always let us know⁠ if you experience any issues while trying to run it. If you want to contribute to our mission, consider donating⁠ to Ersilia!